Cell–cell and cell–matrix interactions
نویسنده
چکیده
Intracellular interactions shape cells Intestinal epithelial cells build a brush border of microvilli at their apical surfaces that mediates nutrient absorption and host defense. Scott Crawley (Tyska Laboratory, Vanderbilt University Medical Center) showed that brush border assembly is driven by trans interactions between protocadherin-24 and mucin-like protocadherin at the tips of adjacent microvilli. Loss of this adhesive complex causes irregularities in the length and spacing of these protrusions and contributes to the intestinal pathology seen in a mouse model of Usher syndrome.
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